This is a more advanced version of the previous interactive graph where you were able to take into consideration the contributions of renal clearance and the relative contributions of CYP2D6 and non-CYP2D6 mediated metabolic clearance. In this interactive graph, there are no parameter and dosage assumptions. The user has complete freedom in setting values for any of the PK and dosing parameters. It does however, require that the user knows the parameter values to use. If you are uncertain about these, better to use the previous graph

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Using the control panels in the right side bar:

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1. Input values for Bioavailability, Rate of Absorption and Volume of Distribution.

 

2. Next, select and input the renal clearance. .

 

3. Specify an approximate % contribution of renal clearance to the total clearance. This automatically estimates the total metabolic clearance.

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4. Specify the % contributions of non-CYP450 and polymorphic CYP450 clearance. This  automatically calculates the polymorphic CYP450 clearance of an Extensive Metabolizer. (You can view a short video on the CYP2D6 genetic polymorphism here.)

 

5. Specify the patient's CYP450 phenotype (It can represent any CYP450). This will recalculate the % contributions of the various routes of clearance.

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6. If you hit the Randomize button, the programme will generate a randomized patient based on these initial inputs

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7. Amend the dosage regimen as often as you want by adding a new dosage regimen.

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8. Input the tablet size and details of the starting dosage regimen.

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9. Introduce a drug interaction by moving the sliders, and specifying the dose # when you want to begin the interaction.

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Have fun!

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