Humour 2 | pharmacoltutorials

Drug-induced dystonic reactions

Potent D2 dopamnine receptor antagonists are prone to induce dystonic reactions such as spasmodic or sustained contractions of facial and neck muscles.

star Trek Discovery - CYP2D6

Capt Philippa Georgiou, of the USS Shenzhou is Chinese? Who'd imagine? In any case she is an intermediate metabolizer for CYP2D6.

Captain America has urticaria?

Anti-histamines are not consistently useful in urticaria... largely because its aetiology and pathogenesis are uncertain.

Punisher with the wrong dose

We seldom dose women differently even though we understand that women and men do have different pharmacokinetics. Consider, for starters, how different the genders are with respect to body weights, body proportions with respect to fat and lean body mass.

Indocyanine Green

Indocyanine green is used in medical diagnostics. It is rapidly bound to albumin and exclusively taken up into hepatic parenchyma.

CYP2C9 Poor Metabolizer

Wafarinis metabolized by CYP2C9. Poor metabolizers have reduced ability to breakdown warfarin and require lower doses.

Sublingual

Sublingual route of administration theoretically bypasses intestinal and hepatic first pass metabolism if it is absorbed throught the buccal mucosa. Unfortunately much of the dissolved drug is swallowed instead.

Scopalamine

Scopalamine (hyoscine) together with atropine are active extracts from Atropa belladonna. 'Belladonna' presumably because of dilation of pupils? Scopalamine not only dilates the pupils but also possesses the whole range of anti-muscarinic effects, including difficulty in micturition. Was Rose using scopalamine for her motion sickness on the Titanic?